Friday, 24 July 2015

Depression & Low Co-Enzyme Q10 Levels

A study from 2009 has found that individuals with depression have lower plasma levels of a vitamin-like substance called Co-Enzyme Q10.

The study also found that the lower plasma levels of Co-Enzyme Q10 were associated with treatment resistance and chronic fatigue.

The low Co-Enzyme Q10 levels were also found to be a risk factor for developing cardiovascular disease in depressed patients.

Another study on CFS(Chronic Fatigue Syndrome) and Co-Enzyme Q10 levels unearthed similar findings, which can explain the early mortality from heart disease in these type of individuals.

Which makes low Co-Enzyme Q10 a very important pathophysiology in those who suffer from depression and chronic fatigue, if they want to prevent heart disorders.

There is now evidence from recent scientific research that major depression is accompanied by an induction of inflammatory, oxidative and nitrosative stress pathways and a lowered antioxidant status.

Co-Enzyme Q10 is a vitamin-like substance that is involved in energy(ATP) production, which also has potent antioxidant and anti-inflammatory properties, helping to lower oxidative stress.

As someone who suffered from CFS(Chronic Fatigue Syndrome) and major depression myself, i had my Co-Enzyme Q10 levels tested privately and not surprisingly they came back severely deficient(as pictured below).

Clinical improvement especially relating to energy levels and mitochondrial dysfunction can be seen, once Co-Enzyme Q10 levels are restored.  I noticed a big improvement in mood also from Ubiquinol.

The study concluded:

The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression. It is suggested that depressed patients may benefit from CoQ10 supplementation. 
The findings that lower CoQ10 is a risk factor to coronary artery disease and chronic heart failure (CHF) and mortality due to CHF suggest that low CoQ10 is another factor explaining the risk to cardiovascular disorder in depression. Since statins significantly lower plasma CoQ10, depressed patients and in particular those with TRD and CFS represent populations at risk to statin treatment.

Ubiquinol is the reduced form of Co-Enzyme Q10, which studies show to be about 8 times better absorbed than regular Co-Enzyme Q10 supplements.

Purchase Ubiquinol Capsules from Natu Health Store below.


1.  Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness.

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